Animal Models of Diabetes and Metabolic Disease 2014

نویسندگان

  • Tomohiko Sasase
  • Norihide Yokoi
  • Marcus G. Pezzolesi
  • Masami Shinohara
چکیده

1Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka 569-1125, Japan 2Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan 3Section on Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA 4Tokyo Animal & Diet Department, CLEA Japan, Inc., Tokyo 153-8533, Japan

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Influence of Securigera securidaca on Diabetes Management in Animal Models: A Systematic Review

Background and Objective: It has been reported that allopathic drugs do not have significant effects on diabetes treatment. In contemporary literature, much attention has been given to the potential use of traditional medicines, including medicinal plants, in the treatment of metabolic abnormalities. Indeed, the effect of Securigera securidaca, as a medicinal agent, in alleviating the complicat...

متن کامل

مدل‎های حیوانی ایجاد دیابت

In this article, we review animal models of types 1 and 2 diabetes mellitus. Models of type 1 diabetes are discussed in two parts, genetic and chemical. Models of type 2 diabetes are discussed in four parts – rat and mouse models, dietary induction, and selective breeding. Models are assessed regarding metabolic disturbances, the condition of the pancreas, long-term complications, and research ...

متن کامل

Role of adiponectin in metabolic and cardiovascular disease

Under disease conditions including obesity (insulin resistance) and diabetes, dysregulation of adipokines such as tumor necrosis factor (TNF)-α, leptin, resistin, and adiponectin contribute to the development of metabolic and cardiovascular disease. Unlike other adipokines, adiponectin has been shown to be a therapeutic target for metabolic syndrome and cardiovascular disease. Circulating level...

متن کامل

Effects of Type 1 and Type 2 Diabetes on Micro-Anatomical Changes of Adrenal Gland in Male Wistar Rats

Background & Aims: Changing the hormonal output of endocrine glands, diabetes leads to the occurrence of secondary metabolic disorders. Neuropathy, on the other hand, is the most common neurological complication of diabetes which affects the neuroendocrine system, in addition to peripheral and autonomic nervous system, contributing to exacerbation of disease severity. In this line, the present ...

متن کامل

Different Models Used to Induce Diabetes: a Comprehensive Review

Diabetes mellitus is a group of heterogeneous metabolic disorders. A large number of pharmacological agents and animal models are used in study of diabetes for understanding the pathogenesis, complications, genetic and environmental influences. Animal models for type 1 diabetes range from animals with spontaneously developing autoimmune diabetic to chemical ablation of the pancreatic beta cells...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 2015  شماره 

صفحات  -

تاریخ انتشار 2015